Abstract:

BACKGROUND: Golgi protein-73 is a glycoprotein which discovered with the proteomics technology development. It has close relation with acute and chronic hepatitis and hepatocellular cancer.
OBJECTIVE: To investigate the expression of Golgi protein-73 in liver tissue of the patients with benign end-stage liver diseases and normal liver tissue, and to analyze their clinical significance and prognostic value.
METHODS: 113 specimens of liver transplantation for patients with benign end-stage liver disease and 10 normal liver specimens were included in the study. The expressions of Golgi protein-73 in these specimens were detected by immunohistochemistry.
RESULTS AND CONCLUSION: Golgi protein-73 expression levels in specimens of liver transplantation for patients with benign end-stage liver diseases were higher than those in normal liver specimens without liver disease. Golgi protein-73 expression levels in specimens of autoimmune hepatitis cirrhosis were higher than those in hepatitis B cirrhosis. There was no significant difference of Golgi protein-73 expression among all other groups. Golgi glycoprotein 73 expression in autoimmune hepatitis depended non-viral pathway was higher than that in HBV viral way.